Malin Lindqvist Appell Selected Research

thiopurine methyltransferase (thiopurine S-methyltransferase)

1/2021	No association between relapse hazard and thiopurine methyltransferase geno- or phenotypes in non-high risk acute lymphoblastic leukemia: a NOPHO ALL2008 sub-study.
1/2021	Pharmacogenetic studies of thiopurine methyltransferase genotype-phenotype concordance and effect of methotrexate on thiopurine metabolism.
1/2020	The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia.
1/2018	Role of TPMT and ITPA variants in mercaptopurine disposition.
5/2014	Pharmacogenetically based dosing of thiopurines in childhood acute lymphoblastic leukemia: influence on cure rates and risk of second cancer.
11/2013	Comparison of three methods for measuring thiopurine methyltransferase activity in red blood cells and human leukemia cells.
7/2012	Structural characteristics determine the cause of the low enzyme activity of two thiopurine S-methyltransferase allelic variants: a biophysical characterization of TPMT2 and TPMT5.

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Malin Lindqvist Appell Research Topics

Disease

4	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2021 - 07/2012
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 07/2012
2	Neoplasms (Cancer) 11/2016 - 05/2014
2	Leukemia 11/2016 - 11/2013

Drug/Important Bio-Agent (IBA)

7	thiopurine methyltransferase (thiopurine S-methyltransferase)IBA 01/2021 - 07/2012
4	Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric 01/2021 - 11/2016
3	2-mercaptopurineIBA 01/2021 - 07/2012
2	Methotrexate (Mexate)FDA LinkGeneric 01/2021 - 01/2018
2	Inosine TriphosphataseIBA 01/2020 - 01/2018
2	Thioguanine (Tioguanine)FDA Link 01/2018 - 11/2016
1	Nudix HydrolasesIBA 01/2020
1	NucleotidesIBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2016
1	Azathioprine (Imuran)FDA LinkGeneric 11/2016
1	EnzymesIBA 07/2012

Therapy/Procedure

3	Therapeutics 01/2021 - 05/2014